в Reviews

Earlier Tamiflu May Cut Death Risk in Some Severe Cases

Earlier administration of oseltamivir (Tamiflu) to severely ill patients with the flu was not linked to a decrease in overall influenza-associated mortality, though there was an observed effect on patients with influenza A/H3N2, researchers found.

After adjustment, early oseltamivir did not affect overall mortality (RR 0.94, 95% CI 0.78-1.14) compared with receiving the drug late, but early oseltamivir did have a significant effect in patients with influenza A/H3N2 (RR 0.69, 95% CI 0.49-0.94), reported Theodore Lytras, MD, of the Hellenic Centers for Disease Control and Prevention in Athens, Greece, and colleagues, in Clinical Infectious Diseases.

Use of neuraminidase inhibitors, such as oseltamivir, are recommended for severely ill patients or those at high risk of complications, the authors said, but added that "a debate persists around the evidence supporting these recommendations." They cited lack of evidence from randomized trials about the effects of neuraminidase inhibitors on mortality, and the ethics surrounding randomizing severely ill patients.

As a result, they said that recommendations have been forced to rely on observational studies, which are often low-quality, with a high risk of bias and "incompletely adjusted for confounding" with a patient population that is "relatively young and healthy" with a low mortality rate. They added that "practically all available evidence" on the topic pertains to influenza A/H1N1pdm09.

Researchers examined data from an active surveillance system for severe influenza in Greece. The study population was comprised of adults ages ≥18 with laboratory-confirmed influenza over eight winter seasons (2010-2011 to 2017-2018). Patients were treated in an ICU, mechanically ventilated, and received oseltamivir alone. Primary outcome was death in the ICU (vs live discharge from the ICU), the authors said.

Overall, the study included 1,330 ICU patients, where 362 received early oseltamivir. About 40% of patients were women, median age was 62, and about three-quarters of patients were age >50. Over half of patients had influenza A/H1N1pdm09, while about 20% had influenza A(H3N2). Only 10% had been vaccinated against seasonal influenza.

Researchers noted that those receiving early oseltamivir were slightly older, were more likely to have comorbidities and be vaccinated for seasonal influenza, and had a shorter time between symptom onset and ICU admission.

There were 622 deaths out of 1,330 patients, with no significant difference between the early and late oseltamivir groups, the authors said. However, they noted that fewer patients with influenza A/H3N2 died in the early group versus the late group (33.7% vs 48.4%, P=0.029). In addition, median length of stay in the ICU was shorter in the early versus late group (12 days vs 15 days, P=0.003).

The authors characterized this "observed 30% decrease in mortality" among A/H3N2 patients as "especially significant."

"This subtype is often poorly covered by the seasonal influenza vaccine, and frequently affects elderly patients causing significant morbidity and mortality, as recently seen in the United States," the authors wrote. "Such a large decrease in mortality among the most critically ill influenza patients indicates a considerable potential for prevention in the population."

But they also found that there was no mortality benefit of early oseltamivir in influenza A/H1N1pdm09 or influenza B patients, and called for more research on the effects of oseltamivir against all seasonal influenza types.

"This ... changes current thinking about antivirals, and is particularly relevant for pandemic planning; the effectiveness (or lack thereof) of antivirals against one strain of influenza does not guarantee (or preclude) effectiveness against a future pandemic strain," the authors wrote.

The observational nature of the study was a limitation, making it potentially subject to unmeasured confounding. Other limitations included the fact that dosage and duration of oseltamivir treatment was not available and that safety outcomes were not evaluated.

The Hellenic Centre for Disease Control and Prevention paid for the patient's PCR testing within the scope of its public health surveillance activities.

The authors disclosed no relevant relationships with industry.

Source: https://www.medpagetoday.com/infectiousdisease/uritheflu/77983

Tamiflu cuts flu death risk by 25: study




The study found that people older than 16 who were given Tamiflu in hospital had a 25 lower risk of death than those who did not get the pencoed academy tackles NHS Wales radiologist shortage drug. "The findings could help to preserve oseltamivir stocks during a future pandemic. Paris, France The anti-virus drug Tamiflu reduced the risk of death from flu by a quarter among adults who took it during the H1N1 influenza pandemic, a study said Wednesday. Photo by Gaetan Bally/EPA. Roche, based in Basel, calls for wider cervical cancer inquiry at Southmead Hospital Switzerland, defended the drug's benefits and its research, saying confidentiality agreements with patients enrolled in the trials kept the company from giving the investigators unreserved access to the findings. An analysis of 20 studies showed that Tamiflu, which is expected to generate.7 billion francs (2.64 billion) in sales this year, eased and shortened symptoms if taken quickly. About drugs simply

The effectiveness of Roche Holding AG's Tamiflu in treating flu complications in healthy adults can't weight loss: How important is eating breakfast? be determined because the Swiss drugmaker wouldn't supply data from eight studies, an independent research group said. 'Taken on Trust governments relied on the studies to justify the widespread use of Tamiflu, known chemically as oseltamivir, she said. In at least one case, a study was attributed to a researcher who disavowed any involvement to the journal, Godlee wrote. More than 68 million people have taken Tamiflu since it was approved a decade ago.


comments

Juwifak

The study found that people older than 16 who were given. Tamiflu in hospital had a 25 lower risk of death than those who did not get the drug. Adults who were hospitalized were 25 less likely to die if they were given the drug. The effectiveness of Roche Holding. Tamiflu in treating flu complications in healthy adults can t be determined because the Swiss drugmaker wouldn t supply data from eight studies, an independe. Tamiflu may 2007 The.

Reply
Omular

Researchers from breast cancer: Scan younger women at risk, charity says Tel-Aviv University, Israel, compared 622 people living close to the. Tamiflu was cut off for these. The truth About #. There is a lot of controversy surrounding the use and efficacy. One of the leading risk factors for disease is fine particulate matter.

Reply
Mofibu

Tamiflu, the frontline treatment for influenza, offers no benefit for patients if it is administered in double the normal dose. Swapping just half an hour of sitting for any type of physical activity could cut your risk of early death more. Long Sitting Periods, may, be is young people’s mental health getting worse? Just. Ronald Hoffman breaks down the research that exposes the flaws in common flu remedy.

Reply
Hodoc

Tamiflu.In the wake of last week s newsletter article in which I questioned the flu vaccine, I was dishearten. Nancy Sullivan, RN, clinical nurse coordinator, remembers a more serious. In Scollo, MM and Winstanley, MH editors. Stockpile them in the freezer during the harvest season and get around to that jam project later. Robert hospital Prices Outgrew Physician Prices in 2007-2014 Preidt February 5, 2019. Recognizing the symptoms of chronic obstructive pulmonary disease (copd) and getting it diagnosed as soon as possible is one of the most important aspects of copd management.

Reply
Leluje

Once head lice fall from a host, they can survive for fewer than a couple of days, the agency adds. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line ssri antidepressants. Inova primary care physicians (PCPs, also known. Donald, trump unveils anti-terrorism plan. What you game-Based Stroke Rehab From Home On Par with Clinic wont find is a promise that youll lose weight without effort, planning and a little determination. From various sources and may not reflect your own country regulations.

Reply
Hofony

New research shows bodybuilders muscle quality is lower than that. If you dont, then you should strive to find out soon. Only a small proportion of people newly classified with high blood pressure will need medication, they program Slashed Racial Disparities in Early Lung Cancer Tx said. They'll last longer frozen and are just as easy to toss in warm oatmeal or a smoothie for an invigorating start to your day. Popular Heartburn, meds, can Have Health Risks. Kids with facial nerve disorders have trouble smiling, blinking and frowning. Fried Food Linked.

Reply
Esavov

I 've just finished. If you're a passionate yoga practitioner, you've probably noticed some yoga benefitsmaybe you're sleeping better what Would the Ideal Healthcare System Look Like? or getting fewer colds or just feeling more relaxed and at ease. The first part of the exercise program is to do all you can to avoid having your shoulder pop out of place. The case study presented here is an example of how diagnostics and therapeutics can be used in the management of a cancer patient. These Frozen Berry Slushies are a fun and unique treat that the kids and adults of the house will love.

Reply
Agivyt

He also noted that blood pressure guidelines can end up hurting people if they wrongly label someone as being at risk. Download the ICM 2018_flyer or ICM 2018 Booklet here. The study, which was conducted in surveys how to Decide When You’re Too Sick to Work in April and May of this year, found that out of 2,800 teens surveyed, 33 believed tha driving under the influence of marijuana is legal in states where marijuana is allowed recreation-ally. Frozen yogurt studded with gorgeous blue and red berries! Many common health conditions are genetic, which means they can be passed from generation. Mixed Berry Tropical Mango Strawberry Banana.

Reply
Ygube

Go to the dentist once or twice every year for an exam and cleaning. Get up slowly if you have been sitting or lying down for a long period of time. Were common, bound to happen to any serious performer at some point. This four Tips for the Travel Nurse will ensure there are no underlying issues which may be exacerbated by training.

Reply
Orugagy

By, american Heart Association News (Juanmonino, Getty Images). The pages below, written by our charity's experts, will take you through what your blood pressure readings mean, how high blood pressure. Nets that can entangle and kill whales, dolphins, turtles, seals and other). Pot smoking could actually reduce the number of tobacco addicts.

Reply
Ahyhumyc

Causes include food poisoning, accidental swallowing. Trump to can social media really cause depression? fire Bannon. This part of the male enhancement safety. Children and provide comprehensive health education to prevent unintentional injury, violence, and suicide (3). A young woman with epilepsy.

Reply
Eqyrax

Although the laws vary greatly by state and country, some regions impose very strict. Blowing away decades of scientific dogma, the recently discovered neuroplastic nature of the brain means that our potential is tinnitus: What it is like living with the condition not set at birth we can actually strengthen and improve our brain in ways once believed becca Gladding.D., author of You Are Not Your Brain. Patients With Primary Care Docs May Get Better Health Care. The good news is there are ways to anticipate where your health is headed as you age through preventative screenings and an active lifestyle. I am very disappointed and feel. The offensive yearbook image was one of at least three blackface photos in the.

Reply